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Your doctor may decrease 減少 your dose of ceritinib or tell you to stop taking ceritinib for a period of time during your treatment.

This will depend on how well the medication works for you and any side effects 副作用 you may experience.

Be sure to tell your doctor how you are feeling during your treatment 治療 with ceritinib.

Before taking ceritinib,

• tell your doctor and pharmacist if you are allergic to ceritinib, any other medications, or any of the ingredients in ceritinib capsules. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention 提及 any of the following: (以下為藥名) antacids 制酸劑 ; anticoagulants 抗凝血劑 ('blood thinners') such as warfarin (Coumadin, Jantoven); beta blockers β受體-阻斷劑 such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); carbamazepine 治療癲癇用藥 (Carbatrol, Epitol, Equetro, Tegretol, Teril); certain medications 某些藥物 for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); corticosteroids; cyclosporine (Gengraf, Neoral, Sandimmune); dihydroergotamine (D.H.E. 45, Migranal); diltiazem (Cardizem, Dilacor, Tiazac); ergotamine (Ergomar); fentanyl (Abstral, Actiq, Duragesic, Fentora, Subsys); ketoconazole (Nizoral); medications to control your blood pressure; medications for indigestion, heartburn, or ulcers such as cimetidine (Tagamet, in Duexis), esomeprazole (Nexium), famotidine (Pepcid), lansoprazole (Prevacid), nizatidine (Axid), omeprazole (Prilosec), pantoprazole (Protonix), rabeprazole (AcipHex), and ranitidine (Zantac); nefazodone; methadone (Dolophine, Methadose); phenytoin (Dilantin, Phenytek); pimozide (Orap);, quinidine; rifampin (Rifadin, Rimactane, in Rifater); sirolimus (Rapamune); tacrolimus (Astagraf, Prograf); telithromycin (Ketek); and verapamil (Calan, Covera, Isoptin, Verelan). Many other medications may interact with ceritinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor what herbal products 草藥產品 you are taking, especially St. John's Wort 聖約翰草.
• tell your doctor if you have or have ever had diabetes 糖尿病 or high blood sugar 高血糖, heart failure 心臟衰竭 , an irregular heartbeat 心律不齊, QT prolongation QT間期延長 (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death), or liver or heart disease 肝臟或心臟疾病.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should use birth control to prevent pregnancy during your treatment and for at least 2 weeks after your treatment. Talk to your doctor about birth control methods that will work for you. Ceritinib may harm your unborn baby. If you become pregnant during your treatment with ceritinib, call your doctor immediately.
• tell your doctor if you are breast-feeding. You should not breast-feed while you are taking ceritinib.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking ceritinib.
• you should know that you may experience hyperglycemia (increase in your blood sugar) while you are taking this medication. Tell your doctor immediately if you have any of the following symptoms while you are taking ceritinib: extreme thirst, frequent urination, extreme hunger, blurred vision, trouble thinking or concentrating, breath smells like fruit, or tiredness.

Ceritinib may cause side effects 副作用 . Tell your doctor if any of these symptoms are severe or do not go away:

• nausea 噁心
• diarrhea 腹瀉
• vomiting 嘔吐
• constipation 便秘
• stomach pain 胃痛
• heartburn 胃灼熱
• difficulty swallowing 吞嚥困難
• fatigue 疲勞
• rash 皮疹
• changes in vision 視力變化

Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:

• pain in the right upper part of the stomach
• unusual bruising or bleeding
• dark urine
• yellowing of the skin and eyes
• decreased appetite
• flu-like symptoms
• itching
• shortness of breath
• fever, chills, sore throat, ongoing cough and congestion, or other signs of infection
• chest pain or discomfort
• changes in heartbeat
• heart palpitations
• dizziness
• lightheadedness
• fainting

Ceritinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.